Comparing long acting pain meds?

It sounds like cost is a huge limiting factor. Unfortunately, most of the delayed release drugs are quite expensive. It also sounds like you have concerns about taking long-acting drugs. What about just using the immediate-release oxycodone around the clock instead of taking anything long-acting at all? Also, I think methadone is an excellent idea. It is really an outstanding drug and takes a little bit of an experienced doctor to manage it. I would also note the when drug addicts take it (methadone maintenance), they only take it once a day, whereas for chronic pain, it is generally taken about 3-4 times per day. If I were you, I would go for the methadone. I am not sure if it more difficult to be weaned off than any other opioid. I have met patients who were incredibly addicted to Oxycontin, Vicodin, and other pain meds.